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The growing biopharmaceutical industry, coupled with rising demand for affordable biologics such as biosimilars and generic drugs, has resulted in the increased outsourcing of manufacturing activities by biotech and pharmaceutical companies to contract manufacturing organizations (CMOs). CMOs offer cost-effective and time-efficient solutions for clinical and commercial manufacturing of biologics. One of the most widely used production platforms by CMOs is Escherichia coli (E. coli), which is preferred for its fast growth, high protein yield, and capabilities for extensive genetic manipulation. E. coli enables rapid, high-yield, and cost-effective production of recombinant proteins on an industrial scale. The global GMP Protein (E. coli) Contract Manufacturing Market is estimated to be valued at US$ 685.8 Mn in 2023 and is expected to exhibit a CAGR of 9.7% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.
Market key trends:
One of the major trends in the GMP Protein (E. coli) Contract Manufacturing Market is the rise of gene-editing technologies. CRISPR/Cas9-mediated gene editing has revolutionized E. coli engineering approaches for enhanced and optimized recombinant protein production. CRISPR/Cas9 provides a straightforward way to knock out, repair, or insert genes in E. coli, accelerating development timelines and improving yields. Several CMOs are utilizing CRISPR/Cas9 technology to develop superior E. coli strains customized for specific clients and recombinant protein targets. Another key trend is the growing adoption of continuous processing techniques. Continuous processing allows for greater control over culture conditions, reduces contamination risks, and improves product consistency compared to batch workflows. Leading CMOs are investing in continuous bioprocessing equipment to modernize their facilities and meet emerging industry demands.
Porter’s Analysis
Threat of new entrants: Low barrier for new players to enter the market. However, high capital requirement and need for established credentials pose challenges for new entrants.
Bargaining power of buyers: Growing preference for tailored services provides buyers with bargaining power to negotiate on pricing and turnaround times.
Bargaining power of suppliers: Risk of forward integration from CMO players poses a threat. Suppliers of raw materials and components have moderate bargaining power.
Threat of new substitutes: Threat from alternate production platforms is moderate. Advancements in biosimilars and cell-based production hold potential but are not strong substitutes currently.
Competitive rivalry: Intense competition exists among established players to expand capacity and capabilities. Price wars and frequent M&As between players to gain larger market share.
Key Takeaways
The global GMP Protein (E. coli) Contract Manufacturing Market is expected to witness high growth. The market size for 2024 is estimated to be US$ 685.8 Mn, indicating a CAGR of around 9.7% during the forecast period of 2023 to 2030.
Regional analysis: North America dominates currently led by robust biopharmaceutical industry in the US. Asia Pacific shows high growth potential with increasing outsourcing trends and investments in biotech infrastructure in China, India.
Key players: Key players operating in the GMP Protein (E. coli) Contract Manufacturing Market are Merck & Co., Inc., Thermo Fisher Scientific Inc., Abcam plc, GenScript, and Syngene.
*Note:
- Source: Coherent Market Insights, Public sources, Desk research
- We have leveraged AI tools to mine information and compile it
